Course: Bacterial Genomes: Antimicrobial Resistance in Bacterial Pathogens

Usage of antibiotics in healthcare In the presence of antibiotics, minor resistant bacterial populations have a selective growth advantage and proliferate while the others die out. Inappropriate use or misuse …

Mixed mechanisms Resistance genes can be mobilized within or between bacterial cells using a combination of mechanisms previously explained. A particular resistance gene can be flanked by a transposon allowing …

Overview Intrinsic resistance is when a bacterial species is naturally resistant to a certain antibiotic or family of antibiotics, without the need for mutation or gain of further genes. This …

You have a bacterial infection and are prescribed an antibiotic by a doctor. Within a few days you begin to feel better. But how do antibiotics work? In broad terms …

Antibiotics – the basics You may have heard both the terms “antimicrobial” and “antibiotic”. Although often used interchangeably, they actually have distinct meanings: Antimicrobial: is any substance that kills or …

When comparing the phenotypic drug susceptibility results to the genomic determinants identified, there could be some cases with discrepancies. These can occur because of the following reasons: 1. Phenotype sensitive …

Principles of the procedure The aim of this procedure is to determine if bacteria are susceptible or resistant to a range of different antibiotics. This is done by plating a …

In this video, Professor Sally Davies talks about how big the problem of antimicrobial resistance is, and what are the strategies to tackle it

In this video, Dr. Estée Török talks about her work on translating microbial sequencing from a research tool into clinical practise. Her particular interest is the antimicrobial resistance and health …

Introduction to recent Cholera epidemics Cholera is an acute diarrhoeal disease caused by ingesting food or water contaminated with the bacterium Vibrio cholerae. Some people develop water diarrhoea with severe …

What are phylogenetic trees? A phylogeny, also known as phylogenetic tree, depicts estimated evolutionary relationships between taxa – these can be species, strains or even genes. In the context of …

In this video, you will learn how to use Microreact, a free web tool developed by the Centre for Genomic Pathogen Surveillance at the Wellcome Genome Campus.

In the step to follow, we will use ACT to analyse a representative Salmonella Typhi genome (labelled as BL0006) of the extensively drug resistant (XDR) Typhoid outbreak you have been …

Your learning You will learn by watching videos, reading articles and publications, doing exercises, checking your understanding in the quizzes and the final test, and through discussion with other learners. …