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Grading in Clinical Practice Guidelines

Prof. Mary Ferrill clarifies grading in CPGs and major inconsistencies in this video. To begin with, there are 5 grades or levels in total. Firstly, the studies in GRADE A …

Introduction: Clinical Practice Guidelines

Prof. Mary Ferrill gives a brief introduction to clinical practice guidelines (CPG) and the learning objectives for this lesson. To begin with, it is very important for us to be …

Clinical Practice in NI studies

Prof. Mary Ferrill gives three examples to make sure that we are able to apply the knowledge on studies. She starts this video with three questions. Can superiority be concluded …

How to Assess the NI Margin?

Prof. Mary Ferrill explains how to evaluate P values, power, and mainly the NI margin in this video. When interpreting P values in NI, we have to keep in mind …

Translating Confidence Intervals Graphically

Prof. Mary Ferrill clarifies how to compare ITT and Per Protocol and how to translate CIs graphically. First, remember ITT means intention to treat, and the traditional definition is that …

Null Hypothesis Formulation: Purpose and Errors

Prof. Mary Ferrill gives a clear illustration of how to analyze an Non-Inferiority (NI) trial. To begin with, we have to learn the differences between superiority and non-inferiority. In addition, …

What is the Number Needed to Treat?

In this article, the author explore the factors (beyond the efficacy of a therapy) that influence the number needed to treat and that must be taken into account when comparing …

Conclusion: NNT/NNH Comparative Numbers

Prof. Mary Ferrill gives a summary of this lesson. Continuing from the previous video, we can find the confidence intervals in this example are extremely wide, which indicates the data …

An Example to check HR, RRR, and NNT

In this video, Prof. Mary Ferrill continues to explain RR, RRR (Relative RIsk Reduction), ARR (Absolute Risk Reduction), and NNT/NNH in the clinical trial. We are given an example from …

How to Calculate RR, RRR, ARR, and NNT/NNH ?

Prof. Mary Ferrill explains how to calculate RR, RRR (Relative RIsk Reduction), ARR (Absolute Risk Reduction), and NNT/NNH. She starts this video with a table about the exposure and outcome …