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Diagnosing type I allergic reactions

Diagnosis of immediate type allergies should be based on a four-column principle. This principle consists in a detailed anamnesis, followed by a physical examination of the skin and mucosa. Positive …

Food allergies

Plant-based allergens include fruits, nuts, kernels, seeds, vegetables, grains, and spices. Animal-based allergens encompass milk, egg, fish, crustaceans, poultry, and rarely meat. Sensitization frequencies vary with type of food and …

Respiratory allergies

In respiratory allergies, the allergens are typically proteins from airborne particles. There are four main allergen-carrier groups: pollen, animal danders, fungi as well as insects and mites. The two most …

Atopic disorders on the rise

How are the discovery of a disease and its prevalence related? The cause of hay fever was found only at the end of the 19th century and allergies seemed to …

Insect sting allergies

Local inflammatory reactions to stinging (eg bees and wasps), biting and blood-sucking insects (eg fleas, lice, and cockroaches) and acari (eg mites, ticks, and spiders) are very common. Typically, red …

Symptoms of type I allergic reactions

Type I (immediate type) allergies present themselves with characteristic symptoms in different organs. The release of histamine, leukotrienes, and other inflammatory mediators from mast cells and basophils act on skin …

Mechanism of type I allergic reactions

The adaptive immune system is central in any immune defence, including allergic reactions. Before the body reacts to foreign intruders, it first has to encounter the antigen and identify it …

Coombs and Gell classification

In 1963, two British immunologists, Robert Coombs and Philip Gell, published in a book a new scheme for classifying different types of hypersensitivity reactions. Although knowledge on the underlying immunological …

Case: a carriage ride in Central Park

Welcome back! We are very glad that you have decided to continue your journey in the world of allergies together with us. In the second week you will recognize manifestations, …

Allergies: a box with various compartments

In this video you will learn about the importance of the allergic history of a person and why a combination of substances or activities can result in an allergic reaction, …

The immune defence as a battlefield

If we imagine the immune defence as an allegorical castle, there are numerous dangers that may assail it. They include not only attackers from the outside, but also dangers from …

Introducing the metaphor

The immune system uses intricate processes to defend our organism. In this sense it may be compared to a castle. In fact, the metaphor of a castle that protects from …

Clandestine arsonists

Arachidonic acid, kinin, or complement cascades: these names all stand for pathways, which may become activated in an immune reaction. Through these so-called cascades, multiple factors such as leukotrienes, prostaglandins, …

A complex network I: where it happens

The immune defence is an intricate network. Its many options and simultaneous processes are not easy to grasp. One helpful approach to its complexity is to define the place of …