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Overview of this week

What can you expect to learn from this week? Professor Daniel Brown is going to explain the topic: The Challenges of Assessing Renal and Hepatic Clearance Summary of Week 4: …

What happens when volume increases?

Prof. Brown explains the situation for an increase in volume (V). If volume (V) doubles, we should double dosing interval (tau) and the dose at the same time, or simply …

Protein binding: the impact of unbound drug

Prof. Brown begins with summaries of how parameters changing affects serum concentration(C) and AUC. We should understand the reason and the relationship instead of simply memorizing them. He also clarifies …

Overview of this week

What do we expect to learn from this week? Professor Daniel Brown is going to explain the topic: The Ups and Downs of Predicting Changes in Drug Concentration Summary of …

Summary: The keys to optimal drug dosing

Prof. Brown gives the keys to optimal drug dosing, including linearity, superposition, and accumulation in this video. Which factor(s) decides the time takes to reach steady state? Is it k, …

The concept of an accumulation factor

We can regard % lost as an “Accumulation Factor”. With dose, volume (V), elimination rate constant (k), C times zero (C0), and tau, we can calculate e to the minus …