Course: Clinical Pharmacokinetics: Dosing and Monitoring

Prof. Brown demonstrates Cockcroft-Gault, MDRD, and CKD-EPI with an example of renal function lab report. He uses real data to illustrate the differences. Prof. Brown also discusses common drugs that …

In this part, we can learn two sources of error: body weight, and very low muscle mass (or paralysis). We need to know how to adjust a patient’s creatinine clearance …

Welcome to the new chapter. Prof. Brown gives a clear outline of this lesson, and clarifies the terms of drug disappearance in our body. Glomerular filtration rate, which can be …

What can you expect to learn from this week? Professor Daniel Brown is going to explain the topic: The Challenges of Assessing Renal and Hepatic Clearance Summary of Week 4: …

Prof. Brown describes the whole process of the ups and downs in serum concentration (C), from the moment fu increases until steady-state is reestablished. The final brain exercise is about …

Prof. Brown begins with summaries of how parameters changing affects serum concentration(C) and AUC. We should understand the reason and the relationship instead of simply memorizing them. He also clarifies …

Prof. Brown explains the situation for an increase in volume (V). If volume (V) doubles, we should double dosing interval (tau) and the dose at the same time, or simply …

A change in clearance (CL) is a big issue. Prof. Brown uses a graph and a table to describe how it influences serum concentration (C) and AUC. We can learn …

Finishing a brain exercise for measuring a drug serum concentration (C), Prof. Brown starts to explain how to adapt the dose and dosing interval (tau). The changes in volume (V) …

We can learn the timing to measure serum levels in this part. Besides, we need to know which factor(s) affects Cav,ss ? Which factor(s) affects Cmax,ss and Cmin,ss? The relationship …

What do we expect to learn from this week? Professor Daniel Brown is going to explain the topic: The Ups and Downs of Predicting Changes in Drug Concentration Summary of …

Read this paper “Pharmacokinetic-Based Design and Modification of Dosage Regimens” by Reza Mehvar, which was published in the American Journal of Pharmaceutical Education in 1998. Reza had shown a early …

Prof. Brown gives the keys to optimal drug dosing, including linearity, superposition, and accumulation in this video. Which factor(s) decides the time takes to reach steady state? Is it k, …

We can regard % lost as an “Accumulation Factor”. With dose, volume (V), elimination rate constant (k), C times zero (C0), and tau, we can calculate e to the minus …