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General questions 7 : Carbamazepine

Continuing from the previous step, Prof. Lee explains the seventh general question this time. From this case, we can know that Carbamazepine is greater than 99% metabolized, which means liver …

General questions 1

Prof. Lee explains the first general question 1 : Drug A is primarily excreted unchanged in the urine, dosage adjustment is usually necessary when the patient’s creatinine clearance is_______mL/min. When …

A case for Vancomycin : 2

Continuing from the Vancomycin case in the previous step, Prof. Lee explains how to calculate dosing interval and maintenance dose this time. When we get the dosing interval, remember to …

A case for Vancomycin : 1

In this step, Prof. Lee gives an example to demonstrate dosing Vancomycin. We will learn the whole process dosing Vancomycin in patients in renal failure, including calculating elimination rate constant …

A case for Gentamycin : 2

Continuing from the previous step, Prof. Lee illustrates the other questions this time. First, we can calculate volume of distribution (V) since we already have elimination constant rate (k), infusion …

A case for Gentamycin : 1

Prof. Lee uses a brief case for Gentamycin to demonstrate the previous discussed idea. Do you still remember how to calculate the half-life and peak concentration? Please try the following …

Single and Multiple Intermittent Infusion Equations

Prof. Lee introduces single and multiple intermittent infusion equations in this step. He starts with single intermittent infusion. To begin with, he illustrates how to calculate the concentration at any …

TDM : Examples : Phenytoin & Digoxin

In this step, Prof. Lee gives two examples of TDM and summarizes this week. For Phenytoin, we must know that it has concentration-related toxicity. When the serum concentration is over …

Example 4 : Carboplatin

Continuing, Prof. Lee explains how to calculate the oral maintenance dose of digoxin and how to estimate Carboplatin clearance. First, we can assume that the bioavailability of digoxin is 0.7, …

Tobramycin Dosing Regimen : Example 2

In this video, Prof. Lee demonstrates the steps to estimate the dosing regimen of Tobramycin. To begin with, we can see that in the first diagram, the y-axis is the …