Course: Pharmacokinetics: Drug Dosing in Renal Disease

Continuing from the previous step, Prof. Lee illustrates the eighth and the ninth general question this time. For the eighth question, there is a specific equation for aminoglycosides: 0.00293 times …

Continuing from the previous step, Prof. Lee explains the seventh general question this time. From this case, we can know that Carbamazepine is greater than 99% metabolized, which means liver …

In this step, Prof. Lee discusses two general questions. The fifth one is about the volume of distribution of digoxin. In renal failure, the tissue uptake of the digoxin by …

Continuing from the previous step, Prof. Lee illustrates 3 general questions this time. For the second general question, it is obvious that we should decrease the dosage since the patient’s …

Prof. Lee explains the first general question 1 : Drug A is primarily excreted unchanged in the urine, dosage adjustment is usually necessary when the patient’s creatinine clearance is_______mL/min. When …

Continuing from the Vancomycin case in the previous step, Prof. Lee explains how to calculate dosing interval and maintenance dose this time. When we get the dosing interval, remember to …

In this step, Prof. Lee gives an example to demonstrate dosing Vancomycin. We will learn the whole process dosing Vancomycin in patients in renal failure, including calculating elimination rate constant …

Continuing from the previous step, Prof. Lee illustrates the other questions this time. First, we can calculate volume of distribution (V) since we already have elimination constant rate (k), infusion …

Prof. Lee uses a brief case for Gentamycin to demonstrate the previous discussed idea. Do you still remember how to calculate the half-life and peak concentration? Please try the following …

Prof. Lee introduces single and multiple intermittent infusion equations in this step. He starts with single intermittent infusion. To begin with, he illustrates how to calculate the concentration at any …

In this step, Prof. Lee explains the 3 major concerns on using Aminoglycosides and Vancomycin in renal failure. The first one is the toxicity. Both of them are known for …

In this step, Prof. Lee gives two examples of TDM and summarizes this week. For Phenytoin, we must know that it has concentration-related toxicity. When the serum concentration is over …

In this step, Prof. Lee illustrates the purpose of Therapeutic Drug Monitoring (TDM), and gives examples for different drugs. To begin with, we know that the side effect could be …

Continuing, Prof. Lee explains how to calculate the oral maintenance dose of digoxin and how to estimate Carboplatin clearance. First, we can assume that the bioavailability of digoxin is 0.7, …

In this step, Prof. Lee illustrates how to estimate the IV digoxin loading dose. We know that we need the volume of distribution (V) by his hint. Therefore, we should …