Course: Pharmacokinetics: Drug Dosing in Renal Disease

Continuing from the previous step, Prof. Lee explains the seventh general question this time. From this case, we can know that Carbamazepine is greater than 99% metabolized, which means liver …

In this step, Prof. Lee discusses two general questions. The fifth one is about the volume of distribution of digoxin. In renal failure, the tissue uptake of the digoxin by …

Prof. Lee explains the first general question 1 : Drug A is primarily excreted unchanged in the urine, dosage adjustment is usually necessary when the patient’s creatinine clearance is_______mL/min. When …

Continuing from the previous step, Prof. Lee illustrates 3 general questions this time. For the second general question, it is obvious that we should decrease the dosage since the patient’s …

Continuing from the Vancomycin case in the previous step, Prof. Lee explains how to calculate dosing interval and maintenance dose this time. When we get the dosing interval, remember to …

In this step, Prof. Lee gives an example to demonstrate dosing Vancomycin. We will learn the whole process dosing Vancomycin in patients in renal failure, including calculating elimination rate constant …

Continuing from the previous step, Prof. Lee illustrates the other questions this time. First, we can calculate volume of distribution (V) since we already have elimination constant rate (k), infusion …

Prof. Lee uses a brief case for Gentamycin to demonstrate the previous discussed idea. Do you still remember how to calculate the half-life and peak concentration? Please try the following …

Prof. Lee introduces single and multiple intermittent infusion equations in this step. He starts with single intermittent infusion. To begin with, he illustrates how to calculate the concentration at any …

In this step, Prof. Lee explains the 3 major concerns on using Aminoglycosides and Vancomycin in renal failure. The first one is the toxicity. Both of them are known for …

In this step, Prof. Lee gives two examples of TDM and summarizes this week. For Phenytoin, we must know that it has concentration-related toxicity. When the serum concentration is over …

In this step, Prof. Lee illustrates the purpose of Therapeutic Drug Monitoring (TDM), and gives examples for different drugs. To begin with, we know that the side effect could be …

Continuing, Prof. Lee explains how to calculate the oral maintenance dose of digoxin and how to estimate Carboplatin clearance. First, we can assume that the bioavailability of digoxin is 0.7, …

In this step, Prof. Lee illustrates how to estimate the IV digoxin loading dose. We know that we need the volume of distribution (V) by his hint. Therefore, we should …

In this video, Prof. Lee demonstrates the steps to estimate the dosing regimen of Tobramycin. To begin with, we can see that in the first diagram, the y-axis is the …